Application examples of sulfobutyl beta cyclodextrin

2022/01/11

Sulfobutabeta cyclodextrin (SBE-β-CD) is an anionic, highly water-soluble β-CD derivative, which can form a non-covalent complex with drug molecules, thereby improving the drug`s Stability, water solubility, safety, reduce nephrotoxicity, ease drug hemolysis, control drug release rate, mask bad smell, etc. Compared with β-CD, it has better water solubility, less hemolysis, and low nephrotoxicity. It is a new type of pharmaceutical excipient with very broad application prospects.
1. Application in injection
Function: Solubilizer and stabilizer, improve the solubility and stability of poorly soluble drugs, and develop poorly soluble drugs into injections. (Example: Use SBE-β-CD to improve the solubility of docetaxel, voriconazole, ibuprofen, and indomethacin; use SBE-β-CD to improve the stability of carmustine)
2. Application in oral preparations
Function: Solubilizer, stabilizer, improve the bioavailability of poorly soluble drugs (example: use SBE-β-CD to increase the bioavailability of flunarizine, danazol, prednisone, and prasugrel)
3. Application in ophthalmic preparations
Function: Solubilizer, stabilizer, reduce drug irritation (example: use SBE-β-CD to improve the irritation and stability of pilocarpine, dipiforin, balofloxacin, and acyclovir)
4. Application in nasal preparations
Function: Increase the permeability of the nasal mucosa, improve the solubility and stability of the drug, and improve the metabolism rate of the drug at the target site (example: use SBE-β-CD to improve the solubility and stability of imidazoline)
5. Ointment
Function: Improve the solubility and stability of the drug (Example: Use SBE-β-CD to improve the solubility and stability of Nimesulide)