Application of sulfobutyl beta cyclodextrin sodium in epidemic situation

2022/01/11

Sulfobutabeta cyclodextrin sodium, the "star excipient" in this global epidemic in 2020, has been advancing all the way due to the popularity of Redecive! So when it comes to sulfobutyl beta cyclodextrin sodium, we have to mention Redecive, the "anti-epidemic drug." Today, the epidemic has spread to every country and region in the world, and countless people have used this drug.

The emergence of Remdesivir can be traced back to 2009, when it was developed for hepatitis C, but in the subsequent process of improving its chemical formula, remdesivir is no longer used as a drug for the treatment of hepatitis C. It is used to inhibit respiratory viruses. After 2014, Gilead found that in vitro tests showed that Remdesivir may be effective against Ebola virus; in 2016 and 2018, a series of safety and effectiveness tests of the drug were conducted on animals and humans. There are 4 treatment options in the whole study, and a total of 673 patient data were analyzed. In the analysis, the safety of Redecivir was verified, but its effectiveness was not as good as the other two options. Therefore, Gilead did not apply for registration of Remdesivir for Ebola virus indications.

Two years later, in 2020, Remdesivir, which has been unknown, has found its place in the epidemic. It first broke into people's vision at the end of January. A 35-year-old man returned to the United States from a family visit in Wuhan on January 15 this year. He was diagnosed with the virus and became the first confirmed case in the United States. On the 7th day of hospitalization, due to the deterioration of his condition, based on the principle of [sympathetic medication" in the United States, the doctors decided to provide him with remdesivir, which was not approved at the time. The next day, his condition improved greatly. An article on the diagnosis and treatment process of the first confirmed case in the United States was published in the New England Journal of Medicine on January 31.

Since the outbreak of the epidemic, the large-scale use of Remdesivir has caused an explosive increase in the amount of sulfobutyl ketone cyclodextrin sodium. Although it was also questioned by the WHO during the period, many countries are still enthusiastic about the pursuit of Redecive.
Today, sulfobutyl beta cyclodextrin sodium is not only well known to more people as an important excipient for Redecivir, but also as a core excipient for many generic drugs.